Evidence-Based Research
Every day, evidence-based studies are published that reinforce the Mouth-Body Connection®, highlighting the strong link between oral health and overall health. This body of evidence underscores our dedication to advancing dental-medical integration and partnering with those who share our mission. By prioritizing oral health, we aim to improve systemic health, reduce annual healthcare costs, and enhance patients’ quality of life. Explore the research below to see the data for yourself.
- Association between periodontitis and blood pressure highlighted in systemically healthy individuals | Hypertension | Aguilera | 2021
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- Prevention of Viridans Group Streptococcal Infective Endocarditis - A Scientific Statement From the American Heart Association | Circulation | Wilson | 2021
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- Association Between Periodontal Disease and Atherosclerotic Cardiovascular Diseases: Revisted | Frontiers in Caridovascular Medicine | Zardawi | 2021
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- Periodontitis and cardiovascular diseases consensus report | Journal of Clinical Periodontology | Sanz | 2019
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- Poor Oral Health and Blood Pressure Control Among US Hypertensive Adults | Hypertension | Peitropaoli | 2018
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- Novel Biomarkers for Cardiovascular Risk Prediction | Journal of Geriatric Cardiology | Wang | 2017
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- High-risk periodontal pathogens contribute to the pathogenesis of atherosclerosis | Postgraduate Medical Journal | Bale | 2017
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- Increasing Evidence for an Association Between Periodontitus and Cardiovascular Disease | Circulation | Stewart | 2016
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- Effect of Comprehensive Cardiovascular Disease Risk Management on Longitudinal Changes in Carotid Artery Intima-media Thickness in a Community-based Prevention Clinic | Archives of Medical Science | Cheng | 2016
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- Gingipains from the Periodontal Pathogen Porphyromonas Gingivalis Play a Significant Role in Regulation of Angiopoietin 1 and Angiopoietin 2 in Human Aortic Smooth Muscle Cells | Infection and Immunity | Zhang | 2015
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- Oral Infections and Cardiovascular Disease | Trends in Endocrinology and Metabolism | Kholy | 2015
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- Bacterial Signatures in Thrombus Aspirates of Patients With Myocardial Infarction | Circulation | Pessi | 2013
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- Changes in Clinical and Microbiological Periodontal Profiles Relate to Progression of Carotid Intima-Media Thickness | Journal of the American Heart Association | Desvarieux | 2013
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- Usefulness of Self-Reported Periodontal Disease to Identify Individuals with Elevated Inflammatory Markers at Risk of Cardiovascular Disease | American Journal of Cardiology | Mochari | 2008
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- Streptococcus Mutans and Cardiovascular Diseases | Japanese Dental Science Review | Nakano | 2007
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- Preventive dental care is associated with improved health care outcomes and reduced costs for Medicaid members with diabetes | Frontiers in Dental Medicine | Lamster | 2022
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- Oral Health Care and Primary Health Care: Stronger Together in Recognizing and Managing Diabetes | American Dental Education Association | Escontrías | 2022
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- Impact of treating oral disease on preventing vascular diseases: a model-based cost-effectiveness analysis of periodontal treatment among patients with type 2 diabetes | Diabetes Care | Choi | 2020
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- Effect of periodontal treatment on diabetes-related healthcare costs | BMJ Open Diabetes Research & Care | Smits | 2020
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- Improved oral hygiene is associated with decreased risk of new-onset diabetes | Diabetologia | Chang | 2020
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- Study links frequent tooth brushing to lower risk of diabetes | Diabetologia | EurekAlert | 2020
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- Benefits of Non-Surgical Periodontal Treatment in Patients with Type 2 Diabetes Mellitus and Chronic Periodontis: A Randomized Controlled Trial | Journal of Clinical Periodontology | Mauri-Obradors | 2017
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- Periodontitis as a possible early sign of diabetes mellitus | BMJ Open Diabetes Research & Care | Teeuw | 2016
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- Dental Care for Diabetics: Better Health, Cost Savings | Dental Trade Alliance | 2013
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- Effect of Periodontal Disease on Diabetes: Systematic review of epidemiologic observational evidence | Journal of Periodontology | Borgnakke | 2013
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- Diabetes and Oral Disease: Implications for Health Professionals | Annals of the New York Academy of Sciences | Albert | 2012
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- Periodontal disease and diabetes - A two way street | Journal of the American Dental Association | Mealey | 2006
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- Periodontal Disease and Mortality in Type 2 Diabetes | Diabetes Care | Saremi | 2005
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- Microglial cell response to experimental periodontal disease | Journal of Neuroinflammation | Almarhoumi | 2023
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- Periodontal health, cognitive decline, and dementia | Journal of the American Geriatrics Society | Asher | 2022
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- Potential mechanisms between periodontitis and Alzheimer's disease | Canadian Dental Hygienists Association | Lamphere | 2022
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- Periodontal dysbiosis associates with reduced CSF Aβ42 in cognitively normal elderly | Alzheimer’s & Dementia Diagnosis, Assessment & Disease Monitoring | Kamer | 2021
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- Burden of Chronic Diseases Associated with Periodontal Diseases: A retrospective cohort study using UK Primary Care Data | BMJ Open | Zemedikun | 2021
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- Inflammation of the Periodontium Associates with Risk of Future Cardiovascular Events | Journal of Periodontology | Van Dyke | 2021
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- Does-response meta-analysis on tooth loss with the risk of cognitive impairment and dementia | Journal of the American Medical Directors Association | Qi | 2021
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- Clinical and Bacterial Markers of Periodontitis and Their Association with Incident All-Cause and Alheizmer's Disease | Journal of Alzheimer's Disease | Beydoun | 2020
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- Porphyromonas gigivalis, Periodontal and Systemic Implications: A Systemic Review | Dentistry Journal | Fiorillo | 2019
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- Porphyromonas gingivalis in Alzheimer’s disease brains | Science Advances | Dominy | 2019
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- Chronic Oral Application of a Periodontal Pathogen Results in Brain Inflammation, Neurodengeneration and Amyloid Beta Production in Wild Type Mice | PLOS One | Illievski | 2018
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- Association between chronic periodontitis and the risk of Alzheimer's disease | Alzheimer's Research and Therapy | Chen | 2017
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- Association between periodontal disease and stroke | Journal of Vascular Surgery | Sfyoeras | 2012
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- Hypertension and Cerebrovascular Dysfunction | Cell Metabolism | Iadecola | 2008
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- Periodontal Disease, Tooth Loss, and Incidence of Ischemic Stroke | American Stroke Association | Joshipura | 2002
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- Oral microflora and pregnancy: A systematic review and meta‑analysis | Scientific Reports | Jang | 2021
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- Periodontal pathogens and preterm birth: current knowledge and further interventions | Pathogens | Terzic | 2021
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- Assessing the Association Between Periodontitis and Premature Birth: A Case-control Study | BMC Pregnancy and Childbirth | Uwambaye | 2021
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- Treating periodontal disease during pregnancy | European Federation of Periodontology | Bobetsis | 2020
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- Periodontal Disease and Pregnancy Outcomes: Overview of Systematic Reviews | JDR Clinical & Translational Research | Daalderop | 2018
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- Role of Maternal Periodontitis in Preterm Birth | Frontiers in Immunology | Ren | 2017
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- Oral Health in Pregnancy | Journal of Obstetric, Gynecologic & Neonatal Nursing | Hartnett | 2016
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- Fusobacterium nucleatum Subspecies Identification by Matrix-Assisted Laser Desorption Ionization | Journal of Clinical Microbiology | Nie | 2015
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- Fusobacterium Nucleatum: A Commensal-Turned Pathogen | Current Opinion in Microbiology | Han | 2015
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- Oral Health Care During Pregnancy and Through the Lifespan | The American College of Obstetricians and Gynecologists | 2013
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- Periodontal Disease: a potential modifiable risk factor limiting conception | European Society of Human Reproduction and Embryology | Hart | 2012
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- The ADA Practical Guide to Patients with Medical Conditions | American Dental Association | Patton | 2012
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- An Examination of Periodontal Treatment, Dental Care, and Pregnancy Outcomes in an Insured Population in the United States | American Journal of Public Health | Albert | 2011
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- Term Stillbirth Caused by Oral Fusobacterium Nucleatum | Obstetrics & Gynecology | Han | 2011
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- Periodontitis: A risk for delivery of premature labor and low-birth-weight infants | Journal of Natural Science, Biology and Medicine | Saini | 2010
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- Periodontal Pathogens and Gestational Diabetes Mellitus | Journal of Dental Research | Dasanayake | 2008
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- Exploring the relationship between periodontal disease and pregnancy complications | Journal of the American Dental Association | Bobetsis | 2006
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- Periodontitis is Associated With Preeclampsia in Pregnant Women | The Journal of Periodontology | Contreras | 2006
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- Periodontal Therapy Reduces the Rate of Preterm Low Birth Weight in Women with Pregnancy-Associated Gingivitis | The Journal of Periodontology | López | 2005
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- Periodontal disease and preterm delivery of low-birth-weight infants | Journal of the Canadian Dental Association | McGaw | 2002
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- Periodontal Therapy May Reduce the Risk of Preterm Low Birth Weight in Women with Periodontal Disease: A Randomized Controlled Trial | The Journal of Periodontology | López | 2002
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- Oral Heathcare Can't Wait - Patient | Dental Trade Alliance | 2023
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- Oral Heathcare Can't Wait - Congress | Dental Trade Alliance | 2023
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- Oral Healthcare Can't Wait - Business | Dental Trade Alliance | 2023
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- Association between preventive dental care and healthcare cost for enrollees with diabetes or coronary artery disease: 5-year experience | Compendium | Borah | 2022
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- Dental Services and Health Outcomes in the New York State Medicaid Program | Journal of Dental Research | Lamster | 2021
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- Reimbursement Rates for Child and Adult Dental Services in Medicaid by State | American Dental Association | 2021
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- Time to Take Gum Disease Seriously | The Economist Intelligence Unit | 2021
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- Effect of Periodontal Treatment on Diabetes-Related Healthcare Costs | BMJ Open Diabetes Research & Care | Smits | 2020
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- Clinical Insights Drive Better Outcomes | Cigna | 2019
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- HMSA: Integrating oral health for total health | Hawaii Medical Service Association | Mugiishi | 2018
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- Improved Health and Lower Medical Costs - Why good dental care is important | Cigna | 2016
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- Economic Costs of Oral Care in the United States in 2014 | American Society of Health Economists | Kelekar | 2016
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- Evaluation of Cost Savings Associated with Periodontal Disease Treatment Benefits | Avalere Health | 2016
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- Oral Health and the Triple Aim: Evidence and Strategies to Improve Care and Reduce Costs | National Academy for State Health Policy | Andrew Snyder | 2015
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- Impact of periodontal therapy on general health evidence from insurance data for five systemic conditions | American Journal of Preventive Medicine | Jeffcoat | 2014
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- The effect of chairside chronic disease screenings by oral health professionals on healthcare costs | American Journal of Public Health | Nasseh | 2014
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- The Mouth: The Missing Piece to Overall Wellness and Lower Medical Costs | United Concordia Dental | 2014
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- The Economic Burden of Head and Neck Cancer: A Systematic Literature Review | PharmacoEconomics | Wissinger | 2014
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- Connections Matter: How Integrating Medical and Dental Data Improves Member Health and Lowers Cost for Employers | Aetna | 2013
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- United Healthcare Medical Dental Integration Study | United Healthcare | 2013
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- An Examination of Periodontal Treatment and Per Member Per Month Medical Costs in an Insured Population | BMC Health Services Research | Albert | 2006
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- Periodontal disease as a risk factor for sporadic colorectal cancer: Results from COLDENT study | Cancer Causes & Control | Janati | 2022
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- Periodontal Disease, Tooth Loss, and Risk of Serrated Polyps and Conventional Adenomas | American Association for Cancer Research | Lo | 2020
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- Mediators of Inflammation – A Potential Source of Biomarkers in Oral Squamous Cell Carcinoma | Journal of Immunology Research | Tampa | 2018
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- Salivary Biomarkers in Cancer Detection | Medical Oncology | Wang | 2017
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- Variations of Oral Microbiota Are Associated with Pancreatic Disease Including Pancreatic Cancer | Gut | Farrell | 2012
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- Oral Microbiota and Cancer | Journal of Oral Microbiology | Meurman | 2010
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- Predictive Periodontitis: The Most Promising Salivary Biomarkers for Early Diagnosis of Periodontitis | Journal of Clinical Medicine | Cafiero | 2021
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- The Potential Impact of Salivary IL-1 on the Diagnosis of Periodontal Disease: A Pilot Study | Healthcare | Kim | 2021
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- aMMP-8 Point-of-Care/Chairside Oral Fluid Technology as a Rapid, Non-Invasive Tool for Periodontitis and Peri-Implantitis Screening in a Medical Care Setting | Diagnostics | Lähteenmäki | 2020
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- Prediabetes/Diabetes Can Be Screened at the Dental Office by a Low-Cost and Fast Chair-Side/Point-of-Care aMMP-8 Immunotest | Diagnostics | Grigoriadis | 2019
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- Novel Biomarkers for Cardiovascular Risk Prediction | Journal of Geriatric Cardiology | Wang | 2017
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- Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies | The Lancet | Sarwar | 2012
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- Gingival crevicular fluid MMP-8-concentrations in patients after acute myocardial infarction | Head & Face Medicine | Ehlers | 2011
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- Time to take gum disease seriously: The societal and economic impact of periodontitis | The Economist Intelligence Unit | 2021
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- Oral Health In America: Advances and Challenges (2021) | National Institutes of Health | 2021
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- Current Knowledge on Correlations Between Highly Prevalent Dental Conditions and Chronic Diseases: An Umbrella Review | Preventing Chronic Disease | Seitz | 2019
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- Association between periodontal pathogens and systemic disease | Biomedical Journal | Bui | 2018
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- Connections Matter: How Integrating Medical and Dental Data Improves Member Health and Lowers Cost for Employers | Aetna | 2013
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- Oral Health: The Silent Epidemic (2010) | Public Health Reports | 2010
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- Oral Health in America: A Report of the Surgeon General (2000) | U.S. Department of Health and Human Services | 2000
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Stay up to date with the latest findings on the Mouth-Body Connection®. New studies are continuously emerging, reinforcing the significance of oral health in improving overall health. Check back regularly to access the most recent research.
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